3α-Reduction of 5α-Dihydrotestosterone by Rat Ventral Prostate
نویسندگان
چکیده
منابع مشابه
Spectrophotometric method for the assay of steroid 5α-reductase activity of rat liver and prostate microsomes.
A simple spectrophotometric method for the assay of steroid 5α-reductase (5α-SR) was developed in which 5α-dihydrotestosterone (5α-DHT) and 5α-androstane-3α,17β-diol (5α-diol), metabolites formed in the NADPH-dependent reduction of testosterone with enzyme sources of 5α-SR, were measured by enzymatic cycling using 3α-hydroxysteroid dehydrogenase in the presence of excess thionicotinamide-adenin...
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A soluble enzyme preparation catalysing the release of adenine from 5'-methylthioadenosine was purified some 30-fold from extracts of the rat ventral prostate. This reaction was completely dependent on addition of inorganic phosphate ions to the assay medium. This absolute requirement for phosphate ions suggests a phosphorolytic cleavage mechanism. After acid treatment, the other product of the...
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ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1972
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.19.97